Chronic kidney disease is associated with a significantly elevated risk of cardiovascular morbidity and mortality. While traditional cardiovascular risk factors such as hypertension, diabetes, and dyslipidemia play a critical role, non-traditional risk factors unique to Chronic kidney disease further contribute to this heightened risk. This abstract explores both traditional and non-traditional cardiovascular risk factors in Chronic kidney disease. Traditional risk factors in Chronic kidney disease include hypertension, diabetes mellitus, dyslipidemia, and smoking. These factors accelerate the progression of atherosclerosis and increase the likelihood of cardiovascular events and are intricately linked to Chronic kidney disease pathophysiology, impacting significantly cardiovascular health. The interplay between traditional and non- traditional risk factors is complex. For instance, Chronic kidney disease -related mineral and bone disorders contribute to vascular calcification, which independently predicts adverse cardiovascular outcomes. Similarly, chronic inflammation, common in Chronic kidney disease, promotes atherosclerosis and endothelial dysfunction, further heightening cardiovascular risk. Understanding the collective impact of traditional and non-traditional risk factors is crucial for effective cardiovascular risk stratification and management in Chronic kidney disease patients. Cardiovascular risk assessment tools tailored specifically for Chronic kidney disease populations should encompass both traditional and non-traditional risk markers. Moreover, interventions targeting these multifaceted risk factors, such as optimal blood pressure control, glycemic management, lipid-lowering therapies, and novel Chronic kidney disease -specific treatments, are imperative to mitigate cardiovascular risk in this vulnerable population.