Background: Rheumatoid arthritis is a chronic systemic inflammatory disease of an autoimmune nature. The small joints of the hands and feet are the primary targets, but it can also be associated with other joints or extra-articular involvement. Autoimmunity, vasculopathy, fibrosis are characteristics of systemic sclerosis, a chronic connective tissue disease. When patients meet diagnostic criteria for both diagnoses, they are considered to have the overlap syndrome. The treatment is individualized and focuses on the current clinical picture.