Exosomes are extracellular vesicles (30–200 nm) that come out of every cell. They include micro-vesicles and apoptotic bodies, and they are very important for communication between cells, epigenetic regulation, and sending messages close (paracrine function) or far away (endocrine function). Exosome era targets and promotes therapeutic and research approaches, from early laboratory or imagery biomarkers to monitoring of prognosis, even though they have not received the green light from the FDA (Food and Drug Administration).